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The Influence of Carbon Dioxide Tension on the Respiration of Normal and Leukemic Human Leukocytes^*

I. Influence on Endogenous Respiration

W. Bicz

(The Fibiger Laboratory, Biological Division, Copenhagen, Denmark^,)

The influence of CO₂ on the respiration of normal and malignant human leukocytes has been studied with the Cartesian diver technic. The following observations were made:

Endogenous respiration of normal leukocytes suspended in Ringer-Locke's solution was slightly but significantly higher than that of myeloid and lymphoid leukemia cells.

Normal leukocytes were able to maintain their respiratory function in vitro for a longer period of time than were malignant leukocytes.

CO₂ stimulated the respiration of both normal and malignant leukocytes, the optimal CO₂ concentration being 1–2 per cent.

Normal and malignant leukocytes did not differ significantly in their response to variations in CO₂ concentration.

^* This investigation was supported by a grant from the Polish Academy of Sciences, the Danish National Research Fund, the Einar Willumsen Foundation, the Anders Hasselbalch Anti-Leukemia Fund, the Irma Foundation, King Christian X's Memorial Fund, the Lady Tata Memorial Foundation, and from Leukemia Society, Inc.

Present address: Institute of Experimental Pathology, Polish Academy of Sciences, Warszawa-Dworkowa 3, Poland.

Address: Frederik V's vej 11, København Ø, Danmark.

Received 6/30/59.