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Tumor Development in Adrenalectomized Rats Given Inoculations of Aged Tumor Cells After Surgical Stress^*

George J. M. Slawikowski

( Department of Surgery, University of Illinois College of Medicine, Chicago 12, Illinois)

Inoculation of Walker 256 tumor cells after surgery yielded tumors in 51.3 per cent of 78 sham-adrenalectomized rats and in only 35.1 per cent of the 168 rats not operated upon, confirming previous findings that operative stress increased host susceptibility to inoculated tumor cells. In the 69 adrenalectomized rats tumor incidence was 66.7 per cent, although adrenalectomy retarded the growth rate of tumors by approximately one-half. In the second experiment, involving re-operation 6 weeks after adrenalectomy, the above results were confirmed: tumor incidence was 64.3 per cent in adrenalectomized, 47.7 per cent in sham-adrenalectomized, and 22.6 per cent in rats not operated upon.

These results suggest that adrenal glands do not contribute to the decrease of resistance to tumor implantation seen after surgery. This deleterious effect of operations was shown to last less than 4 days.

^* Most of the data in this paper are taken from a thesis submitted in partial fulfillment of the requirements for the Degree of Master of Science in Surgery, in the Graduate College at the Chicago Professional Colleges of the University of Illinois, 1959. They were presented in part at the Annual Meeting of the American Association for Cancer Research, in Atlantic City, N.J., on April 11, 1959.

This research was supported by a grant from the American Cancer Society, Illinois Division, Chicago, Illinois.

Formerly: Public Health Service Postdoctoral Research Fellow of the National Cancer Institute.

At present: Captain, MC, USAR; Department of Experimental Surgery, Walter Reed Army Institute of Research, Washington 12, D.C.

Received 6/29/59.