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The Effect of Thyroidectomy and Thyroid-stimulating Hormone on a Transplanted Acute Leukemia in the Fischer Rat

( Department of Anatomy, University of Miami School of Medicine, Coral Gables, Florida)

Since the role of the thyroid in leukemogenesis has not been clearly established, the following experiments were designed to study the effect of thyroidectomy and increased titers of thyroid-stimulating hormone on leukemia development in the Fischer rat under carefully controlled nutritional conditions. In two separate experiments, neither thyroidectomy alone nor thyroidectomy plus TSH injections prior to tumor implantation influenced the course of leukemia development as measured by survival time, rate of tumor growth, and development of a leukemic blood picture. Food consumption was controlled so that the growth rate of both experimental and control animals was the same throughout the experiment.

Received 9/10/59.