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Detection of Antigenic Differences in Isologous Host-Tumor Systems by Pretreatment with Heavily Irradiated Tumor Cells^*

( Institute for Tumor Biology, Karolinska Institutet Medical School, Stockholm, Sweden)

It was confirmed that antigenic differences exist between methylcholanthrene-induced sarcomas of recent origin and their isologous hosts. No similar differences were demonstrable with spontaneous carcinomas and lymphomas of recent origin, while long-transplanted lines could provoke incompatibility reactions, probably due to genetic deviations between host and tumor in the course of time.

^* This work has been supported by grants from the Swedish Cancer Society and by grant C-3700 from the National Cancer Institute, U.S. Public Health Service.

Received 10/ 6/59.

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