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The Concentration of Radioactive Triiodothyronine in Mammary Tumors and Tissues of C3H Mice^*

Karin R. Corey and Jack Gross

( Department of Anatomy, State University of New York, College of Medicine at New York City, Brooklyn, New York)

Tumor-bearing C3H mice were given injections of I¹³¹-labeled triiodothyronine and sacrificed at various intervals from 15 min. to 48 hours later. The concentration of organic I¹³¹ was determiend in tumors and other tissues. Spontaneous and two types of transplanted mammary tumors were studied. The transplanted tumors were the H2712 tumor, an old rapidly growing tumor, and the S-tumor, a recently isolated, slowly growing tumor.

After intravenous injection a rapid concentration occurred in the H2712 tumor during the first 15 min., with only slight changes during the next 8 hours. The concentration in spontaneous tumors appeared to remain constant or even to slightly increase between 1 and 8 hours, while several other tissues decreased in concentration. At 8 hours the tissues were in the following order of decreasing concentration of organic I¹³¹: liver; S-tumor, spontaneous tumor; brain; mammary gland, H2712 tumor, and muscle; plasma. At this time, the mean concentration in the spontaneous tumor was 4.2 times as large, and that in the H2712 tumor 1.9 times as large, as the concentration in plasma. The concentrations in normal tissues were not appreciably altered by the presence of tumors. After subcutaneous injection the distribution of organic I¹³¹ among tissues was similar to that after intravenous injection.

A radioautographic study demonstrated that the radioactivity was localized in cellular material. This was also emphasized by the determination of the concentrations in the H2712 and spontaneous tumors of iodinated serum albumin and sodium iodide, both labeled with I¹³¹.

^* A preliminary report of this work was presented at the meeting of American Association for Cancer Research, Atlantic City, April, 1956.

This investigation was supported by a grant from the United States Atomic Energy Commission under their Contract No. AT (30-1)-1760.

Present address: Department of Physics, Memorial Center, New York, New York.

Present address: Experimental Medicine and Cancer Research, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Received 10/21/59.