This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Corey, K. R. Articles by Gross, J. Search for Related Content PubMed PubMed Citation Articles by Corey, K. R. Articles by Gross, J.

Labeled Iodinated Compounds in Tumors and Tissues of C3H Mice after the Injection of I¹³¹-labeled Triiodothyronine^*

Karin R. Corey and Jack Gross

( Department of Anatomy, State University of New York, College of Medicine at New York City, Brooklyn, New York)

Tumor-bearing C3H mice were injected with I¹³¹-labeled triiodothyronine and sacrificed at 1, 4, and 8 hours later. The I¹³¹-labeled compounds in mammary tumors, mammary gland, muscle, and plasma were separated by paper chromatography.

During the course of this work a previously unidentified contaminant, in the triiodothyronine solution, was identified as 3,3'-diiodothyronine on paper chromatographic evidence.

Triiodothyronine accounted for most of the organic I¹³¹ in the tissues and was accompanied by various amounts of iodide. In addition, a compound tentatively identified as 3,3'-diiodothyronine accounted for 10 per cent of the activity in plasma and tumors, and for 4–5 per cent in muscle and mammary gland.

^* This investigation was supported by a grant from the United States Atomic Energy Commission under their contract No. At (30-1)-1760.

Present address: Department of Physics, Memorial Center, New York, N.Y.

Present address: Experimental Medicine and Cancer Research, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Received 10/21/59.