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The Local Oncogenic Response of Hamster Tissues to Polyoma Virus

( Laboratory of Pathology, National Cancer Institute,^* Bethesda, Maryland)

Tissues from newborn hamsters or cotton pledgets were bathed in fluids from tissue cultures infected with polyoma virus and implanted into the subcutaneous tissues of 47 immature hamsters. Twenty-seven of the hamsters developed tumors at the site of implantation. No tumors developed in contralateral subcutaneous sites of control implants or in other subcutaneous sites, although tumors were found in the viscera of twelve of the animals. This evidence indicates that the oncogenic effect of the polyoma virus is local rather than systemic. The subcutaneous tumors are transplantable, and six have been maintained as growing transplants through three to twelve serial passages. Although all of the tumors are of mesenchymal cell origin, the six transplantable tumors have shown different characteristics in morphology and behavior which have been retained through the transplant generations.

^* National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare.

Received 10/30/59.