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Effect of Vincaleukoblastine on Metastatic Choriocarcinoma and Related Trophoblastic Tumors in Women

( Endocrinology Branch, National Cancer Institute, Bethesda, Md.)

An alkaloid, Vincaleukoblastine, has suppressed tumor growth and activity in five of eight women with methotrexate-resistant, metastatic trophoblastic disease. In three of these patients the urinary gonadotropin excretion reached normal levels, and in two other patients there was a decrease in pulmonary metastases. Reversible toxic effects have included bone marrow depression with severe leukopenia, alopecia, and neurotoxicity.

Received 1/14/60.