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On Tumor Formation in Gonadal and Hypophyseal Transplants into the Anterior Eye Chambers of Gonadectomized Rats^*

Stig Kullander

( Biological Department, Antoni v. Leeuwenhoekhuis, Amsterdam)

Small pieces of ovarian, testicular, or ovarian plus hypophyseal tissue were transplanted to the anterior eye chambers of rats, aged 2 months, which were simultaneously gonadectomized. One year after the operations the animals were examined. The ovarian and testicular grafts had taken and had been transformed to tumors in a very high percentage of cases. The ovarian and testicular tumors were morphologically similar to each other, and both had estrogenic as well as androgenic properties. Ovarian and hypophyseal grafts in the same eye grew rapidly into large tumors (granulosa-cell tumors and chromophobic hypophyseal adenomas), with signs of progesterone and prolactin secretion, respectively. One of the animals had a mammary adenocarcinoma, and the mammary glands in all were highly stimulated and secreting milk.

It is concluded that prolactin may stimulate the growth and influence the secretion of granulosa-cell tumors. Gonadal and mammary tumors are discussed in relation to the experimental results.

^* This work was supported by a grant from the Anna Fuller Fund, which is gratefully acknowledged.

Present address: Department of Obstetrics and Gynaecology, University Hospital, Lund, Sweden.

Received 1/25/60.