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Ehrlich-reacting Protein in Kidneys of Tumor-bearing Rats^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, and Sloan-Kettering Division Cornell University Medical College, New York, N.Y.)

A basic protein has been isolated from the kidneys of Jensen sarcoma-bearing Sprague-Dawley rats which is not present in the kidneys of normal animals of the same strain. The purification and isolation of this protein can be analytically followed because it gives a strong colored reaction with Ehrlich reagent.

The protein, obtained in crystalline form, has been shown to behave as a single component electrophoretically and in the ultracentrifuge. A significant positive correlation has been shown to exist between the amount of this protein present in the kidney extracts and the weight of the tumor.

^* This research has been partially supported by an American Cancer Society Grant TA6.

Received 7/27/59.