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Incorporation of Amino Acids into Microsomal Proteins of Normal and Malignant Tissues^*

( Merck Institute for Therapeutic Research, Rahway, N.J.)

Rapidly proliferating normal and malignant cells had a greater initial rate of amino acid incorporation into microsomal proteins than did normal cells. The rate of microsomal protein renewal in Novikoff hepatoma was greater than that of liver cells. The initial rates of amino acid incorporation into hepatoma and liver ribonucleoprotein particles were approximately equal. The soluble fractions of the liver and hepatoma cells were essentially interchangeable. Hepatoma microsome and pH 5 enzymes had a greater proportion of ribonucleic acid (RNA) in RNA plus proteins than did normal liver microsomes.

^* The following abbreviations are used: RNP, ribonucleoprotein; 3-PGA, 3-phosphoglycerate; DOC, sodium deoxycholate; PEP, phosphoenol pyruvate.

Received 2/15/60.