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Meta-bis-(2-chloroethylamino)-DL-phenylalanine in the Treatment of Mouse Tumors^*

( Department of Biological Sciences, Stanford Research Institute, Menlo Park, Calif.)

The activity of m-bis-(2-chloroethylamino)-DL-phenylalanine against four tumors in mice—Sarcoma 180, Mammary Cancer 755, Leukemia 1210, and Sarcoma 91—was compared with the para analog. The meta compound appeared to be more active than para compound against S-180, S-91, and Ca-755; it appeared to be slightly less active against L1210. Although the mice were able to tolerate about twice as much of the para analog as the meta analog, the meta analog was active at lower dose levels.

^* This work was carried out under the auspices of the Cancer Chemotherapy National Service Center, National Cancer Institute, U.S. Public Health Service, Contract No. SA-43-ph-1909 and U.S. Public Health Service Grant No. CY4548.

Received 2/ 2/60.