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Cellular Reactions Following Tumor Growth with Special Reference to Plasma-cellular Response

( Department of Pathology and Cancer Research Centre, Assam Medical College, Dibrugarh, Assam, India)

The local and remote cellular reactions of the host following tumor growth have been described. During the course of progressive growth of a transplanted (Rd/3 and Walker) and induced tumor in rats, the regional lymph nodes and spleen increased in weight, associated with the development of a characteristic plasma-cell response accompanied by diminution of lymphocytic tissue, while there was a slight local reaction and scanty plasma-cell accumulation around the tumor graft.

Induced tumor inhibition and regression were associated with an increased local host reaction around the tumor, consisting of an increased accumulation of plasma cells.

Following regression of the transplanted tumor, the animal became resistant to a second graft of the same tumor at a different site. Heat-killed tumor grafts which were no longer capable of stimulating this plasma-cell response failed to render the host resistant to subsequent inoculation of living tumor cells.

It was concluded that the plasma-cellular response is the morphological manifestation of an immune reaction, due to antigenic stimulation from these tumors, and that the plasma cells are involved in the production of antibodies. Judged by the plasma-cellular reaction, transplantation immunity to tumor and normal tissues conforms with the immune state generated by bacterial and other foreign protein antigens.

Reticulum cells contributed to the formation of plasma cells.

Received 3/ 7/60.