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Ultrastructural Changes Occurring in the Transition of the Adenocarcinoma 755 from the Solid to the Ascites Form^*

( Departments of Anatomy and Biochemistry, Emory University, Atlanta 22, Ga.)

A fine structural analysis of the Adenocarcinoma 755 in the solid and ascites forms has shown that considerable alterations occur in the conversion of the solid into the ascites form and vice versa.

The cells of the ascites form displayed a pronounced polarization of the formed elements in juxtaposition with the indentations present in the nucleus.

Particles which may represent virus were detected in both solid and ascites forms, within the cavities of the endoplasmic reticulum and in the form of groups surrounded by a dense membrane.

^* This investigation was supported in part by PHS research grants nos. CY-3528 and C-3916 from the National Cancer Institute, Public Health Service.

Received 3/17/60.