This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Waisman, H. A. Articles by Wang, H. L. Search for Related Content PubMed PubMed Citation Articles by Waisman, H. A. Articles by Wang, H. L.

Biochemical Investigations on a Transplantable Rat Leukemia^*

I. Transplantability of Strains 302 and J

( Sarah A. Workman Pediatric Research Laboratories, Department of Pediatrics, University of Wisconsin, Madison, Wis.)

Two strains of lymphatic leukemia, J and 302, have been maintained through hundreds of successive intraperitoneal injections of spleen tissue from leukemic donors. The two strains appeared to be similar pathologically, but were chemically dissimilar. The J leukemia had white cell counts of 500,000–1,000,000 cu. mm. with enlarged spleen and no jaundice. The 302 strain had markedly enlarged liver, slightly enlarged spleen, and easily observable jaundice terminally. The ease of maintenance of the two strains of leukemia provides an opportunity for biochemical, metabolic, nutritional and chemotherapeutic studies.

^* Supported in part by grant CY-3258 from the United States Public Health Service, The Leukemia Society, Inc., New York; and the Research Committee of the Graduate School of the University of Wisconsin.

Received 3/29/60.