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Biochemical Investigations on a Transplantable Rat Leukemia

II. Liver Phosphatases and Glucose Balance^*

( Sarah A. Workman Pediatric Research Laboratory, Department of Pediatrics, University of Wisconsin, Madison, Wis.)

Glucose-6-phosphatase and fructose 1,6-diphosphatase activity per 100 gm. body weight was shown to be markedly increased in the liver cells of rats bearing two strains of leukemia (J and 302) when compared with normal animals. No differences in liver succinic acid dehydrogenase activity could be demonstrated between normal, J, and 302 leukemic animals. Leukemic animals failed to give an additional glucose-6-phosphatase response to a 50 per cent sucrose diet, whereas normal animals gave a marked response. The white blood cells infiltrating the leukemic livers were excluded as a source of the increased glucose-6-phosphatase or fructose 1,6-diphosphatase activity. A marked decrease in liver glycogen and blood glucose were noted in both strains, whereas the blood lactic acid values were elevated fourfold.

^* Supported in part by grants from the United States Public Health Service, American Cancer Society, Leukemia Society, Inc., New York; and the Research Committee of the Graduate School of the University of Wisconsin, Madison.

Received 3/24/60.