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Heterologous Transplantation of Mouse Tumors into the Newborn Albino Rat^*

John S. Thompson and Clifford W. Gurney

( Argonne Cancer Research Hospital,^, and the Departments of Medicine, The University of Chicago, Chicago 37, Ill.)

Progressive growth fatal to the host resulted when three rapidly growing ascites-forming mouse tumors, the lymphosarcoma 6C3HED, lymphoma L4946, and Ehrlich ascites were injected intraperitoneally into newborn albino rats. Serial passage through newborn rats has not altered their lethality to this heterologous host or to their indigenous mouse host.

Two rapidly growing mouse tumors which do not form ascites, the lymphoma P1534 and neuroblastoma C1300, regularly grew to demonstrable size by the 10th day after subcutaneous injection into newborn rats. Although the neuroblastoma always regressed, the lymphoma P1534 occasionally grew progressively, but serial passage was unsuccessful.

Three relatively slow-growing mouse tumors—the myeloma X5563, mammary carcinoma BW10232, and melanoma S91—did not grow in newborn rats.

Considerable mortality occurred in those rats given injections of the mouse tumors at birth, whether transplantable growth was ever present or not.

^* This investigation was supported by the United States Atomic Energy Commission and the United States Public Health Service.

Public Health Research Fellow of the National Cancer Institute.

John and Mary R. Markle Scholar in Medical Sciences.

Operated by The University of Chicago for the United States Atomic Energy Commission.

Received 4/13/60.