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The Effect of Sarcoma 180 and Other Stressing Agents upon Adrenal and Plasma Corticosterone in Mice^*

( Squibb Institute for Medical Research, New Brunswick, N.J.)

Studies were conducted to determine the influence of progressive tumor growth upon adrenal function of the host. Tumors, adrenals, thymus glands, and plasma, from Swiss mice bearing Sarcoma 180, were removed at frequent intervals. Thymus weight decreased during progressive tumor growth. Adrenal weight changes indicated an early hypertrophy followed by a decrease. Adrenal corticosterone was initially elevated and, after 8 days of tumor growth, decreased to below normal levels through day 14. A secondary increase was then noted, terminal levels being above control levels. Plasma corticosterone followed a similar pattern but with the changes lagging behind those in the adrenal by 1–2 days. Other types of stress were induced and compared with the stress of tumor growth. From the corticosterone patterns obtained, it would appear that a growing tumor induces an adrenal response not unlike a nonspecific chronic stress situation.

^* Work done under Contract No. Sa-43-ph-2395 from the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health.

Presented in part at the 51st Annual Meeting of the American Association for Cancer Research in Chicago, Illinois, April 8–10, 1960.

Received 5/12/60.

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