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Mixed Bacterial Toxins in the Treatment of Tumors

IV. Response of Methylcholanthrene-induced, Spontaneous, and Transplanted Tumors in Mice^*

( Division of Pathology, Institute for Cancer Research; and Dept. of Microbiology, Temple University, School of Medicine, and Oncologic Hospital, Philadelphia, Pa.)

Different preparations obtained from cultures of Serratia marcescens and Streptococcus pyogenes were tested in seven spontaneous, induced, and transplanted tumors of mice, and Rous sarcoma in chicks. The toxins were found to be effective against Krebs-2 carcinoma causing regression of well established tumors. They were found to be ineffective against Sarcoma 180, Gardner's Lymphosarcoma 6C3HED, Carcinoma 755, methylcholanthrene-induced and spontaneous mammary tumors, as well as against virus-induced Rous sarcoma in chicks.

The gross and histopathological changes produced by the bacterial toxins in the tumors and host animals bearing Krebs-2 carcinoma were described and discussed.

The possible role of the Shwartzman phenomenon in the mechanism of bacterial toxin tumor therapy was considered.

^* This work was supported by Grant Cy-2976Cy from the National Cancer Institute, National Institutes of Health, Public Health Service.

Received 6/ 6/60.