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Changes in Epidermal Hydroxyproline and Tyrosine Accompanying Induced Epidermal Carcinogenesis^*

( Radioistope Service, Veterans Administration Hospital, Hines, Illinois)

A marked and progressive decrease in epidermal hydroxyproline accompanied induced epidermal carcinoma by methylcholanthrene in C3H mice. A decrease was also noted in the benzene-treated controls; but this was reversible, whereas the effect produced by the carcinogen was not. A progressive increase in epidermal tyrosine was observed which was more marked in the carcinogen-treated animals than in the controls. Acid hydrolysates of the carcinogen-treated skins produced a darker, humin-like coloration than did those of the controls. The possible origin of this is discussed. The results are interpreted in terms of the sensitivity of fibroblasts to methylcholanthrene.

^* Presented on September 15, 1960, at the 138th annual meeting of the American Chemical Society, New York, N.Y.

Received 7/ 5/60.