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Influence of Urethan on the Development of Spontaneous Leukemia and on the Induction of Hemangiomas in the AKR and C58 Strains of Mice^*

Sadahisa Kawamoto, A. Kirschbaum, M. L. Ibanez, J. J. Trentin and H. G. Taylor

( Pediatrics Section, and Department of Pathology, University of Texas, M. D. Anderson Hospital and Tumor Institute, and Departments of Anatomy and Surgery, Baylor University College of Medicine, Houston, Texas)

In the high-leukemia AKR and C58 strains of mice administration of urethan slightly accelerated the onset of leukemia but did not significantly increase the already high incidence of leukemia.

Urethan induced the formation of hemangiomas of the liver, intestine, and pancreas in both strains of mice. The C58 strain appeared more susceptible, with an incidence of 51 per cent. No hemangiomas were found in the untreated controls.

Hemangiomas occurred much more frequently among nonleukemic mice than among leukemic mice in the urethan-treated groups.

^* This investigation has been supported by research grants CY-2461 and CY-2986 from the National Cancer Institute, Public Health Service.

Present address: Atomic Bomb Casualty Commission, MCAF Navy 955, c/o FPO, San Francisco, Calif.

This work was initiated under the guidance of the late Dr. Arthur Kirschbaum.

Received 8/ 1/60.