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Effects of Administration of Estrogens upon Enzymes of Rat Pituitary II. Aconitase, Succinoxidase, and Transaminase^*

Birute M. Baltrus and Jacklyn B. Melchior

( Department of Biochemistry, Graduate School and Stritch School of Medicine, Loyola University, Chicago, Illinois)

Succinoxidase, aconitase, and glutamic-oxalacetic transaminase have been studied in the pituitary and liver of male rats during the induction of pituitary tumors by treatment with diethylstilbestrol.

In the pituitary the two representatives of the tricarboxylic acid cycle were decreased by approximately the same amount. The changes in these enzymes occurred soon after the beginning of the treatment, and thereafter their activities remained constant, whereas the pituitary slowly underwent marked gross alterations.

Pituitary transaminase first increased and then decreased in both diethylstilbestrol- and placebo-treated animals; thus any effects of the diethylstilbestrol are masked by the placebo effect.

^* This work was supported by grant number EDC 31 of the American Cancer Society, as recommended by the Committee on Growth. Portions of this material have been presented before the American Society of Biological Chemists in April, 1961 (9).

Royal E. Cabell Fellow for 1956. Portions of this work were submitted by Birute M. Baltrus to the Graduate School of Loyola University in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Present address: Chicago College of Osteopathy, Chicago, Ill.

Received 3/15/61.