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Dye-sensitized Photoinactivation of Tumor Cells in Vitro

( Department of Pathology, State University of New York, Downstate Medical Center, and Department of Chemistry, Polytechnic Institute of Brooklyn, Brooklyn, N.Y.)

The in vitro photodynamic inactivation of a wide variety of tumor cells was studied with various dyes used as sensitizers. The capacity of dyes to act as photosensitizers in this system parallels their capacity to sensitize the photoinactivation of many other substrates and correlates with their capacity to undergo photoreduction. Some dyes are able to inactivate tumor cells in the absence of light. Photodynamic inactivation of the tumor cells destroys their tumor-producing capacity but does not change their dye-binding capacity.

^* Public Health Service Research Fellow of the National Cancer Institute.

Received 4/10/61.

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