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The Electrophoretic Mobility of Erythrocytes in Carcinoma and Other Diseases

( Hodgkin's Disease Research Laboratory,^* St. Vincent's Hospital, and New York University School of Medicine, New York, New York)

Data showing the microelectrophoretic behavior of the red blood cells of 700 persons are presented. Represented are healthy persons, patients with various chronic inflammatory diseases, pregnant women, patients with benign tumor, and more than 300 with malignant neoplastic disease.

In many conditions the mobility of the red cell remains unchanged from that of healthy persons. This is true of fracture, mental disease, benign tumor, peptic ulcer of the stomach, ulcerative colitis, and during and after operative procedure. Cancer, and the chronic inflammatory diseases so far studied, cause retardation of the cell's mobility, the former more than the latter. Barring the concurrent presence of inflammatory disease, microelectrophoretic data will enable differentiation of benign from malignant neoplasm, peptic ulcer of the stomach from carcinoma of the stomach. Microelectrophoretic studies should be expanded to include other diseases in order to explore usefulness of the technic to the fullest extent.

^* Supported in part by Joseph Stein Foundation, Henry Nias Foundation, U.S. Public Health Service; and Damon Runyon Foundation for Cancer Research.

With the Technical Assistance of Agnes Dool

Received 6/ 5/61.