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Influence of B. pertussis on Host Survival Following S-180 Implantation^*

( Department of Medicine, Harvard Medical School, Peter Bent Brigham Hospital, and Children's Cancer Research Foundation, Boston, Massachusetts)

Prior conditioning with B. pertussis, a lipopolysaccharide fraction obtained thereform, and the lipopolysaccharide of S. marcescens definitely inhibits successful transplantation of the mouse tumor, Sarcoma 180. The lipoid A component of the endotoxin of E. coli 0111 and the lipide fraction from Sarcoma 180 were without effect.

^* Supported by research grant E1483 from the National Institutes of Health, U.S.P.H.S.

Received 6/22/61.