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Immunohistochemical Study of the Uptake of Serum Proteins by Neoplastic Liver Cells^*

Stanley Cohen, Sam M. Beiser and Konrad C. Hsu

( Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, N.Y.)

The uptake of various exogenous and endogenous serum proteins by neoplastic liver cells was demonstrated with the aid of fluorescein-tagged antibodies to these proteins. The imbibed proteins were found in clusters of intracytoplasmic globules with marked variation in size. In hematoxylin- and eosin-stained sections these globules appeared as round, refractile, and highly eosinophilic inclusions. This distribution contrasted sharply with that observed in Kupffer cells of non-neoplastic liver, where imbibed protein was found only in the form of small granules uniformly dispersed throughout the cytoplasm. Normal liver parenchymal cells did not take up protein.

^* Presented, in part, at the Annual Meeting of the American Society for Experimental Pathology, 1961, Atlantic City, New Jersey. This work was supported, in part, by a grant (G-9768) from the National Science Foundation.

National Science Foundation Student Fellow.

Received 5/25/61.

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