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Multipotential Carcinogenesis with Urethan in the Syrian Golden Hamster^*

( Division of Oncology, The Chicago Medical School, Chicago, Illinois)

Urethan in the drinking water (0.2–0.4 per cent) was administered to 5- to 7-week-old Syrian golden hamsters and continued for 42 weeks with an 8-week interval between the 40th and 48th week. This treatment has been found to give rise to melanotic tumors of the skin, papillomas and carcinomas of the f orestomach, adenomatous polyps of the cecum, pulmonary adenomatosis, mammary tumors, hepatomas, hemangiosarcomas. Certain other tumors occurring in the controls appear to have been enhanced. After the 40th week, all the surviving animals in the urethan-treated groups developed one or more tumors.

^* This investigation was supported by grants C-2893 and CS-9212 from the National Institutes of Health, National Cancer Institute, U.S. Public Health Service.

Received 6/12/61.

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