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The Stathmokinetic Effect of Vincaleukoblastine on Normal Bone Marrow and Leukemic Cells^*

( Children's Cancer Research Foundation and the Department of Pathology, Harvard Medical School, at The Children's Hospital Medical Center, Boston, Massachusetts)

The effect of Vincaleukoblastine (VLB) on mitosis of normal bone marrow cells (DBA/2 mouse) and leukemic cells (L1210 leukemia) was studied. A single dose of VLB (1 mg/kg) injected intraperitoneally caused a metaphase arrest of cell divisions, in both normal bone marrow and leukemic cells. In the ascitic form of L1210 leukemia a transitory prophase inhibition was also produced.

^* Preliminary report presented at the meeting of the American Association for Cancer Research, Atlantic City, April, 1961 (Proc. Am. Assoc. Cancer Research, 3:215, 1961).

This investigation was supported in part by research grants from the National Cancer Institute, NIH, USPHS, #C5427 and #CY3335.

Received 6/22/61.