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Virus-like Particles in Association with L Strain Cells

( Division of Biological Research, Ontario Cancer Institute, Toronto, Canada)

Electron microscope studies of three sublines of Earle's L strain cells showed that in two of the three sublines virus-like particles of type C were present within cytoplasmic vacuoles and outside the cells close to the cell surface. The particles formed by a budding process at the cell membrane. Similar particles were observed in pellets prepared from the medium in which the cells had been grown, and in cells of tumors produced in C3H mice by inoculation of the cultured cells. A second type of particle, type A, was observed within cytoplasmic vacuoles in all three sublines of cells cultivated in vitro. No biological activity has so far been associated with either type of particle.

^* Present address: Department of Cytology. The Rockefeller Institute, New York 21, N.Y.

Received 7/22/60.

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