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Influence of Colchicine on Leukemogenic Effect of X-Ray, Estrogen, Methylcholanthrene, and Urethan in Mice^*

Sadahisa Kawamoto, A. Kirschbaum, J. J. Trentin and H. G. Taylor

( Pediatrics Section, University of Texas M. D. Anderson Hospital and Tumor Institute, and Department of Anatomy, Baylor University College of Medicine, Houston, Texas)

Colchicine had a significant inhibitory influence on the leukemogenic effect of estrogenic hormone in combination with either x-ray or urethan in mice. There was some suggestion that colchicine inhibited the induction of leukemia in mice by x-rays. Colchicine was not leukemogenic in low-leukemia strains of mice when administered alone. Colchicine did not affect spontaneous (presumably viral) leukemogenesis in AKR mice.

^* This investigation has been supported by research grants CY-2461 and CY-2986 from the National Cancer Institute, Public Health Service.

Trainee of U.S.P.H.S. Cancer Research Training Grant CRTY-5021. Present address: Atomic Bomb Casualty Commission, MCAF, Navy 955 c/o FPO, San Francisco, Calif.

This work was initiated under the guidance of the late Dr. Arthur Kirschbaum.

Received 7/29/60.