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Administration of 5-Iododeoxyuridine-I¹³¹ in the Mouse and Rat^*

( Division of Biophysics, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division of Cornell, University Medical College, New York, N.Y.)

5-Iododeoxyuridine-I¹³¹ was administered to normal as well as tumor-bearing rats and mice, and the effect of several variables on the disposition of the administered compound and on the I¹³¹ content of selected tissues was studied. Incorporation of the iodouracil moiety into the DNA of tumor and intestine was demonstrated.

Simultaneous administration of a large excess of 5-iodouridine, together with the 5-iododeoxyuridine-I¹³¹, did not significantly affect the I¹³¹ content of tumor and intestine. Administration of the labeled compound intraperitoneally as an oil emulsion rather than as an aqueous solution appreciably increased the incorporation of the iodouracil moiety into the DNA of tumor tissue. Administration of 5-iododeoxyuridine-5'-phosphate did not appreciably alter the incorporation of the iodouracil moiety as compared with an equimolar dose of 5-iododeoxyuridine.

^* Supported by research grants from the National Institutes of Health (C3811) and the U.S. Atomic Energy Commission (AT-(30-1)-910).

Received 9/ 6/60.