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Searches for Exploitable Biochemical Differences between Normal and Cancer Cells. VIII. Catabolism of Purines and Purine Nucleotides by Sonicates^*

( Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Ala.)

Radioactive purines and purine ribonucleotides were incubated with sonicates of mouse liver, mouse intestine, Adenocarcinoma 755, Sarcoma 180, Leukemia L1210, rat liver, rat intestine, and Novikoff hepatoma, and the residual substrates and the products of catabolism were isolated with the aid of paper chromatography and radioautography. Less catabolism occurred with the tumors than with the livers and intestines, and analysis of the data led to the conclusion that the decreased catabolism was primarily due to decreased xanthine oxidase activity.

^* This work was supported by the Cancer Chemotherapy National Service Center, National Cancer Institute, under the National Institutes of Health Contract No. SA-43-ph-2433, and by grants from the Charles F. Kettering Foundation and the Alfred P. Sloan Foundation.

Affiliated with Sloan-Kettering Institute for Cancer Research, New York, N.Y.

Received 10/14/60.