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The Uptake of Sulfur-35 by the Connective Tissues Surrounding Irradiated Skin Tumors^*

( Laboratory of Pathology, Harvard Cancer Commission and the Cancer Research Institute, New England Deaconess Hospital, Boston, Mass.)

Carcinomas were induced in the interscapular skin of C57L female mice by thrice-weekly applications of benzpyrene. X-radiation of these tumors resulted in an increased incidence of metastasis in irradiated mice compared with unirradiated tumor-bearing control animals. Sulfur-35 was injected into the animals prior to death, and radioautographs of the tumors and tumor beds were prepared. The radioautographs showed a concentration of sulfur-35 in the ground substance and mast cells about unirradiated tumors and reduction in the amount of radioactive material incorporated into similar structures around irradiated tumors.

^* This work was done in part under U.S. Atomic Energy Commission Contract AT(30-1)-901 with the New England Deaconess Hospital and was also supported in part by research grant C-3003 from the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service.

Received 8/18/60.