This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Werner, S. C. Articles by Grinberg, R. Search for Related Content PubMed PubMed Citation Articles by Werner, S. C. Articles by Grinberg, R.

Studies with Mouse Pituitary Thyrotropic Tumors. I. Survival of Implants during Prolonged Suppression by Thyroid Hormone^*

( Department of Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital, New York, N.Y.)

Implants of dependent mouse pituitary thyrotropic tumors survived prolonged suppression of growth with thyroid hormone. With one dependent strain, 3052, no tumor became palpable after implantation in control mice with intact thyroid to 17 months. However, tumors regularly appeared in implanted radiothyroidectomized mice. The latent period to appearance of the tumor decreased with increasing time of suppression with thyroid hormone prior to thyroid ablation. The findings were similar with those of another radiothyroidectomized dependent strain, 4183, kept suppressed by thyroid feeding, then discontinued.

With an autonomous responsive L 24 strain, no tumors appeared in control mice with an intact thyroid, up to 10 months after implantation. Tumors appeared upon radiothyroidectomy, and the latent period was progressively less with more prolonged suppression. After 13 months, however, growths became palpable, even with an intact thyroid.

^* Aided by Contract SA-43ph-2402, Cancer Chemotherapy National Service Center, National Cancer Institute, United States Public Health Service.

Received 10/10/60.