This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rigdon, R. H. Search for Related Content PubMed PubMed Citation Articles by Rigdon, R. H.

Pulmonary Neoplasms Produced by Methylcholanthrene in the White Pekin Duck^*

( Department of Pathology, University of Texas Medical Branch, Galveston, Texas)

Many neoplasms have occurred in the respiratory tract of white Pekin ducks following one intratracheal injection of methylcholanthrene suspended in a 1.0 per cent aqueous solution of polysorbate 80. No tumors occurred when only polysorbate was injected. The histologic type of the tumors varied. Some were neurofibromas, and others were ganglioneuromas, hemangiomas, squamous cell-like carcinomas, adenocarcinomas, whereas still others were unclassified types of neoplasms. Frequently a single tumor showed a variety of histologic patterns. No metastases occurred.

The first tumor was found 56 days after the injection of the carcinogen. Fluorescence studies showed the distribution of methylcholanthrene in the respiratory tract. Methylcholanthrene crystals persisted in the tract for long periods. This technic appears to be very satisfactory for the production of neoplasms in the respiratory tract of the duck.

^* Presented at a meeting of the Pan-American Medical Association, Mexico City, May 2–11, 1960.

This investigation was supported by grants from the National Cancer Institute, Public Health Service (USPH C-1469 (C7) and Tobacco Industry Research Committee.

Received 11/ 1/60.