This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Della Porta, G. Search for Related Content PubMed PubMed Citation Articles by Della Porta, G.

Induction of Intestinal, Mammary, and Ovarian Tumors in Hamsters with Oral Administration of 20-Methylcholanthrene^*

Giuseppe Della Porta

( Division of Oncology, The Chicago Medical School, Chicago, Ill.)

Administration by stomach tube of 36–50 doses of 5 mg. of 20-methylcholanthrene to Syrian golden hamsters resulted in the occurrence of squamous-cell tumors of the forestomach, adenocarcinomas of the small and large intestine, adenocarcinomas of the mammary glands, thecomas of the ovaries, and sebaceous tumors of the skin and ear duct glands. Of these types of tumors, only a few squamous-cell papillomas of the forestomach were observed in control animals. Inflammatory lesions of the intestine with hyperplastic and atypical glands were a common finding in both experimental and control groups.

^* This study was supported by grants CS-9212 and C-2893 of the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

Present address: Istituto dei Tumori, Piazzale Gorini 22, Milan, Italy.

Received 10/26/60.