This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gottfried, B. Articles by Patti, J. Search for Related Content PubMed PubMed Citation Articles by Gottfried, B. Articles by Patti, J.

Effect of Repeated Surgical Trauma on Chemical Carcinogenesis^*

( Waldemar Medical Research Foundation, Port Washington, N.Y.)

C57BL/6 mice given subcutaneous injections of a tumor-producing dose of 3,4,9,10-dibenzpyrene were subjected to either skin wounding or laparotomy. Tumors were induced earlier and progressed more rapidly in the mice subjected to either of the surgical procedures. The mice subjected to laparotomy exhibited the greatest effect of tumorigenesis compared with that in control and skin-wounded mice. The data indicate that surgical trauma acts as a co-carcinogen, augmenting the carcinogenic effect of 3,4,9,10-dibenzpyrene.

^* This investigation was supported in part by grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service and the American Cancer Society.

Received 12/ 1/60.