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Heterotransplantation of Spontaneous Leukemia of AKR Mice into Newborn Rats^*

( Department of Pathology, The University of Chicago, Chicago, Illinois)

Spontaneous lymphoid leukemia of the inbred AKR strain was transplanted into newborn rats, not later than 24 hours after birth. Two intraperitoneal or intravenous injections, spaced 7–10 days apart, resulted in progressive, fatal growth. Single subcutaneous or intraperitoneal injections of leukemic cell suspensions did not establish permanent heterografts. Serial passage was successful in newborn, but not weanling or adult rats. During serial propagation the percentage of takes increased from 40 per cent to nearly 100 per cent, the necessary cell dose decreased sharply, and the time interval between inoculation and death was considerably reduced. The leukemia was converted into the ascitic form by serial intraperitoneal transplantation.

^* This investigation was supported by research Grant C-4311 (C1) from the National Institutes of Health, U.S. Public Health Service.

Received 1/14/61.