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The Effect of Partial Hepatectomy on Subcutaneously Transplanted Hepatomas in Mice^*

( Department of Biology, Brown University, Providence, R.I.)

Experiments were performed to determine the effect of partial hepatectomy on the time of appearance, growth rate, and mitotic activity of subcutaneous hepatoma transplants. Some hepatomas in their early transplant generations appeared earlier in partially hepatectomized than in sham-operated animals and were considered responsive; later generations of these same hepatomas appeared in both groups at the same time and, therefore, were considered to have become unresponsive. Other hepatomas were unresponsive in early as well as later transplant generations. The growth rates and the mitotic indices of all the hepatomas studied were the same in partially hepatectomized and sham-operated animals, which might suggest that, in order to detect responsiveness in a subcutaneous hepatoma, partial hepatectomy should be performed at the time of transplantation.

^* A portion of a thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Brown University, June, 1960.

This investigation was supported by a research grant from the National Cancer Institute (C510) and was carried out during the tenure of a Predoctoral Fellowship from the National Cancer Institute, United States Public Health Service.

Received 1/23/61.