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The Influence of the Age of the Host on the Incidence of Blood-borne Metastases^*

Richard Estensen and Renato Baserga

( Department of Pathology, Northwestern University Medical School, Chicago, Illinois)

The influence of the age of the host on the incidence of metastasis has been studied in mice given injections intravenously of Ehrlich ascites tumor cells. The results indicate that (a) the resistance of mice to the establishment of metastases decreases with age and (b) the influence of age is apparent only at relatively low doses of tumor cells.

^* This work has been supported by a grant from the Illinois Branch of the American Cancer Society.

U.S.P.H.S. Trainee in Pathology.

U.S.P.H.S. Senior Research Fellow.

Received 2/13/61.