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On the Metabolic Effects of 6-Chloropurine

( Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Md.)

6-Chloropurine and 6-chlorouric acid effect specific inhibitions of xanthine oxidase and uricase, respectively, in both slices and homogenates of rat liver. In the rat in vivo, a similarly potent inhibition of uricase is achieved by 6-chlorouric acid, whether administered as such or formed in vivo by the oxidation of 6-chloropurine.

6-Chloropurine in vivo and in liver slices effects only a slight inhibition of nucleic acid biosynthesis as measured by the incorporation of glycine-2-C¹⁴ and of P³². The utilization of acetate for lipide synthesis and the incorporation of glycine in protein are similarly decreased to only a small extent in the presence of therapeutic levels of the drug.

Received 4/ 5/61.