This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Pradhan, S. N. Articles by Steward, J. D. Search for Related Content PubMed PubMed Citation Articles by Pradhan, S. N. Articles by Steward, J. D.

Effect of ThioTEPA on the Synthesis of Protein and Nucleic Acids in Tumor-bearing Mice^*

( Department of Pharmacology, Howard University College of Medicine, Washington, D.C.)

Treatment with three daily doses (3-10 µg/gm each) of thioTEPA inhibited incorporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-1 mouse tumor in a majority of experiments.

In tumors from mice having other treatment schedules and in livers from all groups no definite change in incorporation of these labeled metabolites was observed.

^* Supported by a grant (CY-2854) from the National Cancer Institute, U.S.P.H.S.

Presented at the XXI International Congress of Physiological Sciences at Buenos Aires in August, 1959; an abstract was published in "Abstracts of Communications," p. 220.

Received 8/12/60.