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The Influence of Stilbestrol on Skin Tumors Induced in Mice with Tobacco Tar and Methylcholanthrene^*

( Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kan.)

Experiments were carried out on 400 Swiss female mice to determine the effect of continuous, long-term absorption of stilbestrol on the incidence of skin tumors induced with 3-methylcholanthrene and the neutral fraction of tobacco tar. The incidence of carcinoma in the methylcholanthrene-plus-stilbestrol group was 39 per cent, whereas in the methylcholanthrene-only group the incidence was 17 per cent. Induction times in the two groups were similar. There was no enhancement of malignant tumor formation by stilbestrol among the animals painted with tobacco tar. After 15 months of application there were nine carcinomas among mice given tobacco tar only. Four papillomas occurred in the tobacco tar-plus-stilbestrol group. Keratoacanthomas were observed in several animals.

^* This study was supported by U.S.P.H.S. grant nos. CRT-5006 and CS-9441.

Received 1/13/61.