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Induction of Kidney Tumors in Mice by the Use of 20-Methylcholanthrene-impregnated Strings^*

( Department of Pathology, Ohio State University, Columbus, Ohio)

Cotton strings impregnated with 20-methylcholanthrene were placed in the right kidney of 34 male mice. Nine renal carcinomas and nine spindle-cell sarcomas were produced. Sixteen animals showed no tumor.

Whereas the transitional epithelium of the mouse kidney seems responsive to induction of neoplasia by 20-methylcholanthrene, the renal parenchyma appears resistant.

The method herein presented is recommended as a useful tool for the study of renal carcinogenesis.

^* Supported by Grant C 3125 from the National Cancer Institute.

Received 4/28/62.