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Host Responses to a Transplantable "Ascitic" Tumor^*

Richard Siegler and Irena Koprowska

( Department of Pathology-Cytology Section, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania)

Intraperitoneal inoculation of suspended MT890 "ascitic" tumor cells introduced tumor cells to a very large surface area of the mouse host tissues at one time, thereby greatly magnifying and accelerating the initial host responses and facilitating their study. An early sustained loss of thymic lymphocytes paralleled similar changes in all lymphoid organs. The epithelial cells of the thymus contracted after the cortical lymphocytes were discharged. Rapid mobilization of depot fat and associated fatty change of the liver documented profound metabolic changes which were not reflected in loss of body weight because of fluid retention. In spite of the fact that the tumor grew extensively in the tissues of the peritoneal cavity and tumor cells were present in the blood stream, there was a striking resistance to tumor growth in lymph nodes, spleen, thymus, and bone marrow.

^* This study was supported in part by a research grant, No. CY-3654, from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Present address: Cancer Research Laboratory, Albert Einstein Medical Center, Philadelphia, Pa.

Received 5/ 7/62.