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Oncogenic Properties of Deoxyribonucleic Acid Isolated from Parotid Gland Tumors^*

( Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine; and Department of Medicine, School of Medicine, University of California, Los Angeles, Calif.)

Deoxyribonucleic acid (DNA) was extracted from parotid gland tumors with phenol. The injection of this DNA into 24-hour to 1-week-old AKR mice resulted in a 65 per cent incidence of parotid tumors and/or epithelioid thymomas. Oncogenic properties of the DNA preparation were abolished by incubation with deoxyribonuclease.

Cell-free filtrates of the parotid tumors inoculated into suckling AKR mice did not result in the development of parotid gland neoplasms or thymomas.

It cannot be stated definitely from these experiments whether the oncogenic properties demonstrated are the result of transformation of normal cells by tumor cell nucleic acid or the result of the activity of infectious polyoma virus DNA.

^* These studies were supported by Contract AT(04-1)-GEN-12 between the Atomic Energy Commission and the University of California.

Received 6/22/62.