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Histochemical Observations on Enzymatic Processes of Experimental Carcinogenesis in Hamster Cheek Pouch

( Department of Oral Surgery, Osaka University Dental School, Kita-ku, Osaka, Japan)

Histochemical observations were made of hydrolytic and dehydrogenases during experimental carcinogenesis induced by 9,10-dimethyl-1,2-benzanthracene in a hamster cheek pouch.

Alkaline phosphatase activity was found on the surface of the neoplastic epithelium with heavy inflammation, and nonspecific esterase and ß-glucuronidase had a moderate to high activity in the germinal layer of the neoplastic epithelium. Succinic dehydrogenase activity was shown in the germinal layer, but malic and lactic dehydrogenase reacted more intensely than did succinic dehydrogenase. The hornified layer of neoplasms was devoid of these three dehydrogenases. However, acid phosphatase activity was strikingly present. Aminopeptidase and polysaccharide in neoplasms showed little or no reaction.

Little or no activity of these enzymes was present in the stromal elements of tumors.

Received 6/29/62.