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Effects of Cytoxan on the Proteins of Sensitive and Resistant Strains of the L1210 Leukemia^*

V. Nelle Strozier and William L. Nyhan

( Department of Pediatrics, The Johns Hopkins University, School of Medicine, Baltimore, Maryland)

Carcinostatic doses of Cytoxan were administered to two groups of mice: one bearing a sensitive form of the L1210 leukemia, the other a resistant form. The incorporation of methionine-S³⁵ into protein was investigated in each of these two groups and in untreated controls. In the resistant tumor there was no significant decrease in methionine incorporation following therapy. In the sensitive tumor there was a marked decrease, which was greatest in the nuclear fractions. No effect of Cytoxan was seen in the livers of any of the animals.

These data indicate that the inhibition observed in the formation of tumor proteins following the administration of alkylating agents is related to the biologic action of these compounds and may be directly related to the mechanism of their activity.

^* Aided by grants from The American Cancer Society, The Leukemia Society, and The U.S. Public Health Service (C-4493).

Fellow in Pediatric Research (Training Grant 2A-5275).

Faculty Research Associate of The American Cancer Society.

Received 7/ 7/62.