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Studies on the Utilization of the Carbon of p-Dimethyl-aminoazobenzene for Rat Liver Nucleic Acid Synthesis^*

( Biochemistry Laboratory, Department of Pathology, Menorah Medical Center, Kansas City, Missouri)

The incorporation of p-dimethylaminoazobenzene (DAB) and/or derivatives thereof into rat liver nucleic acid (RNA) has been investigated with N¹⁵- and C¹⁴-labeled DAB. Relatively mild methods of obtaining nucleic acid were used. The data presented indicate that, although the ring components of DAB are not bound to or incorporated into rat liver nucleic acid, the methyl carbon is incorporated to a significant degree. The transfer of this carbon is chiefly into the purine bases, guanine and adenine; comparison with data obtained with formate-C¹⁴ indicates this transfer follows a pathway involving "formate."

^* Supported by a research grant from the American Cancer Society, Inc.

Received 7/18/62.