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Changes in Hepatic Metabolism Associated with Carcinogenesis or Regeneration in Rat Liver^*

( Department of Biochemistry, West Virginia University Medical Center, Morgantown, West Virginia)

The technic of isolated liver perfusion was used to study protein synthesis and amino acid catabolism in normal rat livers, rat livers undergoing azo dye carcinogenesis, and in regenerating rat livers. The results demonstrate that rat livers undergoing carcinogenesis or regeneration have decreased catabolism of amino acids and increased synthesis of protein as compared with normal livers. Although the livers undergoing carcinogenesis and the regenerating livers had a qualitative similarity in amino acid metabolism, they showed quantitative differences when the metabolism of specific amino acids was investigated.

^* These investigations were supported by research grants from the Williams-Waterman Fund, The American Cancer Society, and the United States Public Health Service (National Cancer Institute).

The results of some of these studies were reported at the 43rd Annual Meeting of the Federation of American Societies for Experimental Biology and Medicine in Atlantic City, New Jersey, April, 1959.

Most of these investigations were carried out in the Department of Biochemistry, Seton Hall College of Medicine, Jersey City, New Jersey.

Received 6/26/61.